A Powerful Cryo-EM (CryoEM / CryoTEM) Platform for Efficient Drug Discovery

We typically require 3-5 μL of sample at a concentration of 0.5-3 mg/mL for a standard cryo-EM project. The exact amount depends on the protein size and complexity. Contact us for specific recommendations based on your target.

We recommend sample purity of >95% as assessed by SDS-PAGE or SEC. Homogeneity is equally important — the sample should be monodisperse as confirmed by negative stain EM or DLS before cryo-EM analysis.

Yes, for structure determination services, we require purified protein samples. However, our Protein Production service can assist with expression and purification if needed. We also offer sample optimization consultation.

Samples should be shipped on dry ice or liquid nitrogen depending on stability. We provide detailed shipping guidelines and can arrange pickup for domestic clients. International shipments follow standard biohazard protocols.

Yes, our one-stop service covers the entire workflow from sequence to structure. We handle protein expression, purification, cryo-EM sample preparation, data collection, and structure determination.

Yes, we offer standalone data collection services on both 300kV (Titan Krios G3i/G4) and 120kV (Talos) instruments. You can book beamtime and collect data yourself or have our experts operate.

Pricing depends on the project scope — sample complexity, number of structures, resolution requirements, and whether you need end-to-end service or specific steps. Contact us for a customized quote.

Typical turnaround is 4-8 weeks for standard projects from sample receipt to final model delivery. Complex targets (membrane proteins, small proteins <100kDa) may require 8-12 weeks. Rush services are available.

We support secure data transfer via encrypted cloud storage, dedicated FTP server, or physical hard drive delivery. All transfers use AES-256 encryption to ensure data security.

Your data is strictly confidential. Access is limited to assigned project scientists under NDA. Our facilities comply with industry-standard data security protocols, and all staff sign confidentiality agreements.

The final deliverable includes the 3D density map (EMDB format), atomic model (PDB format), comprehensive validation report (MolProbity scores), and a detailed project summary with micrograph galleries and FSC curves.