Atomic-resolution small molecule structures
MicroED
Micro-crystal electron diffraction for small molecule and drug compound structure determination at atomic resolution, reaching down to 0.65Å.
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Workflow
Crystal Screening
Evaluate crystal quality and select suitable crystals
Data Collection
Continuous rotation data collection on cryo-EM
Processing
Index, integrate, and scale diffraction data
Structure Solution
Solve and refine atomic structure
Report
Deliver CIF file and comprehensive analysis report
Why Choose Shuimu?
Ultra-high Resolution
Resolutions down to 0.65Å for precise atomic-level structure determination
Minimal Sample
Nano-crystals sufficient for complete structure determination
Structures Solved by Shuimu
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Cryo-EM SPA
Single Particle Analysis (SPA) for high-resolution protein structure determination — antibody structures, GPCRs (GPR75), membrane proteins. 2000+ CryoEM projects completed with resolutions reaching 1.4Å.
Cryo-ET Tomography (TOMO)
Cryo-electron tomography (CryoTEM / TOMO) for in-situ structural biology, enabling visualization of macromolecular complexes in their native cellular environment.
EM Characterization
Comprehensive sample screening and quality assessment using advanced cryo-EM techniques to ensure optimal data collection.
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