Cryo-EM structures of the plant plastid-encoded RNA polymerase
Cell (Cover)Mar 2024★ Featured
Publications & Research Papers
55+ peer-reviewed cryo-EM structural biology publications from Shuimu Biosciences (水木未来). Published in Cell, Nature, Science, and more.
3
Cell
5
Nature
2
Science
8
Nature Communications
3
Molecular Cell
3
Science Advances
2
PNAS
55+
Total Papers
2023
Structural insights into the assembly and mechanism of mpox virus DNA polymerase complex F8-A22-E4-H5
Molecular CellNov 2023
Novel, broad and potent spike-specific human monoclonal antibodies inhibit SARS-CoV-2 Omicron sub-lineages
Nature PortfolioNov 2023
An end-to-end approach for protein folding by integrating Cryo-EM maps and sequence evolution
bioRxivNov 2023
Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition
Communications ChemistryOct 2023
Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt tolerance
Nature PlantsOct 2023
Structural insights into the mechanism of GTP initiation of microtubule assembly
Nature CommunicationsSep 2023
Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling
Nature CommunicationsSep 2023
Carotenoid assembly regulates quinone diffusion and the Roseiflexus castenholzii reaction center-light harvesting complex architecture
eLifeSep 2023
Structural mechanism of R2D2 and Loqs-PD synergistic modulation on DmDcr-2 oligomers
Nature CommunicationsAug 2023
Efficient tagging of endogenous proteins in human cell lines for structural studies by single-particle cryo-EM
PNASJul 2023
Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase
Science AdvancesJul 2023
Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility
ScienceJun 2023
Structural basis of α1A-adrenergic receptor activation and recognition by an extracellular nanobody
Nature CommunicationsJun 2023
Structure and transport mechanism of the human calcium pump SPCA1
Cell ResearchMay 2023
Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4
Communications BiologyMay 2023
Dodecamer assembly of a metazoan AAA+ chaperone couples substrate extraction to refolding
Science AdvancesMay 2023
HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography
Communications BiologyApr 2023
Conformational cycle of human polyamine transporter ATP13A2
Nature CommunicationsApr 2023
Dual-Affinity Graphene Sheets for High-Resolution Cryo-Electron Microscopy
JACSApr 2023★ Featured
Structural mechanisms for regulation of GSDMB pore-forming activity
NatureMar 2023
In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV-2 Spike Protein
ACS Central ScienceFeb 2023
Cryo-EM structure of DNA polymerase θ helicase domain in complex with inhibitor novobiocin
bioRxivJan 2023★ Featured
The compact Casπ (Cas12l) 'bracelet' provides a unique structural platform for DNA manipulation
Cell ResearchJan 2023
Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA.1-BA.5
Cell DiscoveryJan 2023
2022
Target RNA activates the protease activity of Craspase to confer antiviral defense
Molecular CellOct 2022
Gossypol Broadly Inhibits Coronaviruses by Targeting RNA-Dependent RNA Polymerases
Advanced ScienceOct 2022
Molecular basis for the selective G protein signaling of somatostatin receptors
Nature Chemical BiologySep 2022
Cryo-EM complex structure of active GPR75 with a nanobody
bioRxivAug 2022★ Featured
Cryo-EM structure of human κ-opioid receptor-Gi complex bound to an endogenous agonist dynorphin A
Protein & CellAug 2022
GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
Molecular CellJul 2022
Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PD
NatureJun 2022
Cross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals
National Science ReviewJun 2022
Structural insights into G protein activation by D1 dopamine receptor
Science AdvancesJun 2022
Ligand recognition and biased agonism of the D1 dopamine receptor
Nature CommunicationsJun 2022
Structural insights into galanin receptor signaling
PNASMay 2022
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
Cell DiscoveryMay 2022
High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV
Cell ReportsApr 2022
Structural basis for the tethered peptide activation of adhesion GPCRs
NatureApr 2022
Receptor binding and complex structures of human ACE2 to spike RBD from Omicron and Delta SARS-CoV-2
CellFeb 2022
Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2
Nature CommunicationsFeb 2022
Structure of IgG-Fc hexamer reveals a mutual lock-and-key mode of Fc-Fc interaction
bioRxivFeb 2022
A bivalent nanoparticle vaccine exhibits potent cross-protection against the variants of SARS-CoV-2
Cell ReportsJan 2022
2021
Cryo-EM structure of mouse TRPML2 in lipid nanodiscs
Journal of Biological ChemistryDec 2021
Two novel human anti-CD25 antibodies with antitumor activity inversely related to their affinity and in vitro activity
Scientific ReportsNov 2021
Atomically Thin Bilayer Janus Membranes for Cryo-electron Microscopy
ACS NanoSep 2021★ Featured
Structures of full-length glycoprotein hormone receptor signalling complexes
NatureSep 2021
Molecular basis for kinin selectivity and activation of the human bradykinin receptors
Nature Structural & Molecular BiologySep 2021
Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants
Cell ResearchAug 2021
Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants
Cell DiscoveryJul 2021
Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors
NeuronJun 2021
Cryo-EM structure of the human histamine H1 receptor/Gq complex
Nature CommunicationsApr 2021
Cryo-electron Microscopy Structure of S-Trimer, a Subunit Vaccine Candidate for COVID-19
Journal of VirologyMar 2021
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