Real-world examples of how Shuimu Biosciences (水木未来) solves challenging protein structures using cryo-EM (CryoEM / CryoTEM). From GPCRs to plant biology to cancer drug targets.
Solving a 56 kDa GPCR complex at the lower cryo-EM size limit
Shuimu solved the world's first cryo-EM structure of active GPR75 in complex with a nanobody, providing a structural template for next-generation anti-obesity drug design. The 56 kDa complex pushed the boundaries of cryo-EM single particle analysis.
Deciphering how plants transcribe their plastid genome
Shuimu determined the cryo-EM structure of the plastid-encoded RNA polymerase (PEP) from plants, revealing the molecular mechanism of chloroplast gene transcription. The work was featured on the cover of Cell.
Structure-guided design of a PARP inhibitor alternative
Shuimu solved the cryo-EM structure of DNA polymerase θ helicase domain bound to the inhibitor novobiocin, providing structural insights for developing alternative treatments for BRCA-mutant cancers.
From 56 kDa GPCRs to multi-subunit complexes, we've solved them all. Let's discuss your project.