In-situ structural biology via Cryo-ET Tomography
Cryo-ET Tomography (TOMO / CryoTEM)
Cryo-electron tomography (CryoTEM / TOMO) enables visualization of macromolecular complexes in their native cellular environment, providing unprecedented insights into cellular machinery organization. Shuimu's cryo-ET tomography service supports structural biology and drug discovery research with in-situ 3D imaging.
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Workflow
Sample Preparation
Cell vitrification or FIB milling for lamella preparation
Tilt Series Acquisition
Automated tilt series collection on Titan Krios
Alignment & Reconstruction
Tilt series alignment and tomogram reconstruction
Subtomogram Averaging
Particle picking and subtomogram averaging for enhanced resolution
Interpretation
Structural interpretation and biological context analysis
Why Choose Shuimu?
State-of-the-art Equipment
Titan Krios with tomography capability for high-resolution in-situ imaging
Expert Team
Experienced scientists specialized in cryo-ET data acquisition and subtomogram averaging
Advanced Processing
Cutting-edge software pipelines for tilt series alignment and reconstruction
Structures Solved by Shuimu
Explore Other Services
Cryo-EM SPA
Single Particle Analysis (SPA) for high-resolution protein structure determination — antibody structures, GPCRs (GPR75), membrane proteins. 2000+ CryoEM projects completed with resolutions reaching 1.4Å.
EM Characterization
Comprehensive sample screening and quality assessment using advanced cryo-EM techniques to ensure optimal data collection.
Data Collection
High-throughput cryo-EM data collection services on 300kV and 120kV instruments with automated processing pipelines.
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