GO
Receptor binding and complex structures of human ACE2 to spike RBD from omicron and delta SARS-CoV-2
Cell. 2022 Feb 17;185(4):630-640.e10.
GraFuture™ Graphene Oxide Support Film
To overcome the bottleneck in cryo-EM sample preparation, Shuimu developed a series of graphene coated grids — GraFuture™, using them to achieve a better reproducibility and efficiency of cryo-EM sample preparation.
Challenges in Traditional Cryo-EM Sample Preparation
Cryo-EM sample preparation using traditional support grids presents:
✕
Air-water interface absorption
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Badly preferred orientation
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Sample concentration threshold (>1μM)
✕
Significant background noise
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Difficulty of reconstructing "small" macromolecules
Unlock Efficiency and Precision with GraFuture™ Grids
GraFuture™ GO
Graphene Oxide Support Film TEM Grid
GraFuture™ RGO
Reduced Graphene Oxide Support Film TEM Grid
GraFuture™ Grids Advantages
GraFuture™ grids could be used with the following advantages:
Graphene Oxide & Reduced Graphene Oxide Specs
≤ 5 layers
thickness
GO / RGO
type
≥ 70%
coverage
Witness Excellence with GraFuture™
Case Studies — GO & RGO
RGO
Structural insights into dsRNA processing by Drosophila Dicer-2–Loqs-PD
Nature. 2022 Jul;607(7918):399-406.
RGO
Structure deformation and curvature sensing of PIEZO1 in lipid membranes
Nature. 2022 Apr;604(7905):377-383.
RGO
Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2
Science. 2021 Jan 8;371(6525):eabe8863.
GraFuture™ GO/RGO Support Film
To overcome the bottleneck in cryo-EM sample preparation, Shuimu developed a series of graphene coated grids — GraFuture™, using them to achieve a better reproducibility and efficiency of cryo-EM sample preparation.
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